Kaplan, J.P., Ye, W., Kileen, H., Liang, Z., Tran, A., Chi, J., Yang, C., Cohen, P., Liman, E.R. 2024. Epitope tagging with genome editing in mice reveals that the proton channel OTOP1 is apically localized and not restricted to Type III “sour” taste receptor cells. J Neurosci. 2025 Feb 5;45(6):e1560242024. doi: 10.1523. (HTML)

Liang, Z., Wilson, C.E., Teng, B. et al. The proton channel OTOP1 is a sensor for the taste of ammonium chloride. Nat Commun 14, 6194 (2023). (HTML)

Bochuan Teng, Joshua P Kaplan, Ziyu Liang, Kevin Saejin Chyung, Marcel P Goldschen-Ohm, Emily R Liman (2023) Zinc activation of OTOP proton channels identifies structural elements of the gating apparatus eLife 12:e85317 (HTML)

Bochuan Teng, Joshua P Kaplan, Ziyu Liang, Zachary Krieger, Yu-Hsiang Tu, Batuujin Burendei, Andrew B Ward, Emily R Liman (2022) Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels eLife 11:e77946 (HTML)

Liman, E.R. and Kinnamon, S.C. Sour Taste:Receptors, Cells and Circuits, Curr Opin Physiol, 2021; 20: 8-15

Teng, B. Wilson, C. E., Tu, Y.T., Joshi, N.R., Kinnamon, S.C., Liman, E.R. Cellular and Neural Responses to Sour Stimuli Require the Proton Channel Otop1. Current Biology, 2019; (published online on Sept 19, 2019). (HTML)

Saotome, K. Teng, B., Tsui, C.C., Lee, W.H, Tu, Y.T., Kaplan, J.P., Sansom, M.S.P., Liman, E.R.*, and A.B. Ward. Structures of the Otopetrin Proton Channels Otop1 and Otop3, Nat Struct Mol Biol 26, 518–525 (2019) (HTML)(Commentary)

Ye W, Tu Y-H, Cooper AJ, Zhang Z, Katritch V, Liman ER. Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers. Scientific Reports. 2018;8(1):17104. doi: 10.1038/s41598-018-35435-y.(HTML)

Tu Y.H., Cooper A.J., Teng B., Chang R.B., Artiga D.J., Turner H.N., Mulhall E.M., Ye W., Smith A.D., Liman E.R. (2018) An evolutionarily conserved gene family encodes proton-selective ion channels. Science 359, 637, 1047-1050. (HTML)(Commentary)

Ye W., Chang R.B., Bushman J.D., Tu Y.H., Mulhall E.M., Wilson C.E., Cooper A.J., Chick W.S., Hill-Eubanks D.C., Nelson M.T., Kinnamon S.C., Liman E.R. (2016) The K+ channel KIR2.1 functions in tandem with proton influx to mediate sour taste transduction. Proc. Natl. Acad. Sci113(2):E229-38. (HTML)

Bushman, J. D.,Ye, W.,  Liman, E. R. (2015). A proton current associated with sour taste:distribution and functional properties. FASEB J. (7):3014-26.

Liman, E. R., Zhang, Y. V., and Montell, C. (2014) Peripheral coding of taste. Neuron 81, 984-1000.

Liman, E.R. (2014) Pain enters through the back door, Nat Chem Biol 10, 171-172.

Gross, G.G., Junge, J.A., Mora, M.J., Kwon^, H.-B., C.,Olson^, A., Takahashi^, T.T.,Liman^, E.R., Ellis-Davies,^, G., McGee^, A.W., Bernardo, S. L., Roberts^, R.W, and D.B. Arnold. (2013) Recombinant probes for visualizing endogenous synaptic protiens in living neurons, Neuron 78(6):971-85

Liman, E.R. (2012) Cell signaling. Putting the squeeze on phototransduction. Science 338, 200-201

Wang, Y. Y., Chang, R. B., and Allgood, S. D., Silver, W. L. and Liman, E. R. (2011). A TRPA1-dependent mechanism for the pungent sensation of wek acids  Journal of General Physiology. 137, 493-505. (PDF) Featured on the cover and in a commentary.

Chang, R. B., Waters, H., and Liman, E. R. (2010). A proton current drives action potentials in genetically identified sour taste cells. Proc Natl Acad Sci U S A. Featured in Nature “Research Highlights“,  468, 603; 2010 and on the cover and in “This week in PNAS”

Wang, Y. Y., Chang, R. B., and Liman, E. R. (2010). TRPA1 is a component of the nociceptive response to CO2. J Neurosci 30, 12958-12963.Featured in “This week in the journal” and on the cover and selected for a “ScienceShot” in Science. http://news.sciencemag.org/sciencenow/2010/09/scienceshot-sodas-spicy-secret.html

Liman, E. R. (2010). A TRP channel contribute to insulin secretion by pancreatic B-cells. Islets, 2(5):331-3. proton

Wang, Y. Y., Chang, R. B., Waters, H. N., McKemy, D. D., and Liman, E. R. (2008). The Nociceptor Ion Channel TRPA1 Is Potentiated and Inactivated by Permeating Calcium Ions. J Biol Chem 283, 32691-32703. 

Lin, W., Ezekwe, E. A., Jr., Zhao, Z., Liman, E. R., and Restrepo, D. (2008). TRPM5-expressing microvillous cells in the main olfactory epithelium. BMC Neurosci 9, 114

Takashima, Y., Daniels, R. L., Knowlton, W., Teng, J., Liman, E. R., and McKemy, D. D. (2007). Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neurons. J Neurosci 27, 14147-14157.

Young, J. M., Waters, H., Dong, C., Fulle, H. J., and Liman, E. R. (2007). Degeneration of the Olfactory Guanylyl Cyclase D Gene during Primate Evolution. PLoS ONE 2, e884.

Zhang, Z., Zhao, Z., Margolskee, R., and Liman, E. (2007). The transduction channel TRPM5 is gated by intracellular calcium in taste cells. J Neurosci 27, 5777-5786.

Zhang, H., Xu, Y., Zhang, Z., Liman, E. R., and Prestwich, G. D. (2006). Synthesis and Biological Activity of Phospholipase C-Resistant Analogues of Phosphatidylinositol 4,5-bisphosphate. J Am Chem Soc 128, 5642-5643.

Zhang, Z., Okawa, H., Wang, Y., and Liman, E.R. (2005). Phosphatidylinositol 4,5-Bisphosphate Rescues TRPM4 Channels from Desensitization. J Biol Chem 280, 39185-39192.

Liu D., Zhang, Z., and Liman, E. R. (2005). Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involves residues in the S3-S4 and S5-S6 extracellular domains ( J Biol Chem. 280(21):20691-20699.

D. Liu and E. R. Liman (2003). Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction channel TRPM5 (PDF) Proc Natl Acad Sci USA (Track II). 100(25):15160-5.
Cited in “faculty of 1000” as “recommended reading.”

E. R. Liman (2003). Regulation by voltage and adenine nucleotides of a Ca2+-activated nonselective ion channel from hamster vomeronasal sensory neurons (PDF) J. Physiol. 548.3:777-787

E. R. Liman and H. Innan (2003). Relaxed selective pressure on an essential component of pheromone transduction in primate evolution (PDF) Proc Natl Acad Sci USA (Track II). 100:3328-3332.
Cited in “faculty of 1000” as “recommended reading.”
Mentioned in “Science News.”

J. F. Rivera, S. Ahmad, M. W. Quick, E. R. Liman, and D. B. Arnold. (2003) An evolutionarily conserved dileucine-containing motif in Shal K+ channels mediates dendritic targeting (PDF) Nature Neuroscience. 3:243-50.

Menco, B.Ph.M. Carr, V.Mc.M., Ezeh, P.I., Liman E.R., and Yankova, M.P. (2001) Ultrastructural localization of G-proteins and the channel protein TRP2 to microvilli of rat vomeronasal receptor cells (PDF) J. Comp. Neurol. 438:468-489.

Liman, E.R., Corey, D.P., and Dulac, C. (1999) TRP2, a candidate transduction channel for mammalian pheromone sensory signalling (PDF) Proc. Natl. Acad. Sci. 96:5791-5796

Liman, E. R., and Corey, D. P. (1996). Electrophysiological characterization of chemosensory neurons of the mouse vomeronasal organ (PDF). J. Neurosci. 16:4625-4637.

Berghard, A., Buck, L. B., and E. R. Liman (1996). Evidence for distinct signaling mechanisms in two mammalian olfactory sense organs (PDF) Proc Natl Acad Sci USA. 93:2365-2369.

Liman, E. R. and L. Buck (1994). A second subunit of the olfactory cyclic nucleotide-gated channel confers high sensitivity to cAMP (PDF) Neuron 13:611-621.

Liman, E. R., Tytgat, J. and P. Hess (1992). Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs (PDF) Neuron 9:861-871.

Liman, E. R., Hess, P., Weaver, F., and G. Koren (1991). Voltage sensing residues in the S4 region of a mammalian K+ channel (PDF) Nature 353:752-756.

Matsubara, H., Liman, E. R.*, Hess, P., and G. Koren (1991). Pretranslational mechanisms determine the type of potassium channels expressed in rat skeletal and cardiac muscles (PDF) J. Biol. Chem. 266:13324-13328, * (co-first author).

Koren, G., Liman, E. R., Logothetis, D. E., Nadal-Ginard, B., and P. Hess (1990). Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells (PDF) Neuron 2:39-51.

Jacobs, L. F. and E. R. Liman (1991). Grey squirrels remember the locations of buried nuts. Anim. Behav. 41:103-110.

Liman, E. R., Knapp, A. G., and J. E. Dowling (1989). Enhancement of kainate-gated currents in retinal horizontal cells by cyclic AMP-dependent protein kinase (PDF) Brain Res. 481:399-402.

Farley, J., Richards, W. G., Ling, L. J., Liman, E., and D. L. Alkon (1983). Membrane changes in a single photoreceptor cause associative learning in Hermissenda. Science 221(4616):1201-3.